Thieno[2,3-d]pyrimidin-4(3H)-one, 3-amino-5-[4-(phenylmethyl)phenyl]-

Name	3-amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one
Synonyms	Barbadin 3-amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one Thieno[2,3-d]pyrimidin-4(3H)-one, 3-amino-5-[4-(phenylmethyl)phenyl]-
CAS	356568-70-2

Molecular Formula	C19H15N3OS
Molar Mass	333.41
Density	1.34±0.1 g/cm3(Predicted)
Melting Point	175-180°C
Boling Point	539.8±60.0 °C(Predicted)
Solubility	Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
Appearance	Solid
Color	White to Pale Yellow
pKa	-1.88±0.20(Predicted)
Storage Condition	Refrigerator

biological activity	Barbadin is a selective inhibitor of β-arrestin/β2-adaptin interaction, the IC50 values for β-arrestin 1 and β-arrestin 2 were 19.1 μm and 15.6 μm, respectively. Barbadin blocking agonists promote endocytosis of the β2-adreneric, V2-vasopressin and angiotensin-II type-1 receptor.
Target	IC50: 19.1 μm (β-arrestin1); 15.6 μm (β-arrestin2)

Last Update：2024-04-09 20:49:11

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